colon

Korean J Gastroenterol. 2006 Feb;47(2):101-10.

Park H.

Department of Internal Medicine, Yonsei University College of Medicine, Yongdong Severance Hospital, Gangnam-gu, Seoul, Korea. hjpark21@yumc.yonsei.ac.kr

Irritable bowel syndrome (IBS) is one of the most common disorders and a heterogeneous condition in view of symptoms and underlying mechanisms. Though underlying causes of pathophysiologic changes remain unclear, low grade mucosal inflammation and abnormal intestinal motility are accepted mechanisms which alter gut function and generate symptoms of IBS. First, before 1980s, abnormal colonic and rectal motor functions were regarded as the main pathophysiology of IBS, but only 25-75% of IBS patients have apparent motor abnormalities which differ from the motor functions in normal controls. So, various gastrointestinal motility tests were not indicated for the diagnosis of IBS.

Gut. 2009 Feb;58(2):196-201. Epub 2008 Sep 29

Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M.

INSERM U913, Nantes, France.

BACKGROUND: Growing evidence suggests that patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. We aimed to investigate (1) paracellular permeability in colonic biopsies of patients with IBS; and (2) the ability of soluble factors from colonic biopsies to reproduce these alterations in vitro.

Research has revealed your IBS Symptoms are caused by a hard-to-see type of inflammation.

“Your IBS Symptoms are NOT caused by ‘too much stress’ or ‘psychological problems’.”

Digestion. 2003;67(4):225-33.

Dapoigny M, Stockbrügger RW, Azpiroz F, Collins S, Coremans G, Müller-Lissner S, Oberndorff A, Pace F, Smout A, Vatn M, Whorwell P.

Service de Gastroentérologie, Hôtel-Dieu, Clermont-Ferrand, France. mdapoigny@chu-clermontferrand.fr

BACKGROUND: Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear.

AIMS: During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food items (including fibers) and IBS symptoms.