nausea

I have a patient (18) whose mom found me on the internet a few months ago, and she initially emailed me explaining her daughter's IBS symptoms and years of visits from doctor to doctor to doctor with no resolution of symptoms and with doctors finally telling her that she was going to have to live with it, or that she wasn't trying hard enough. She found me on the internet, and I remember the last thing she asked me was "Is there no hope?" to which I replied that of course there was, and proceeded to tell her about LEAP.

World J Gastroenterol. 2005 Mar 14;11(10):1540-3.

Wang HH, Shieh MJ, Liao KF.

Division of Gastroenterology, Department of Internal Medicine, China Medical University Hospital, 2 Yuh-Der Road, Taichung, Taiwan, China.

AIM: Racecadotril is a specific enkephalinase inhibitor that exhibits intestinal antisecretory activity without affecting intestinal transit. Loperamide is an effective anti-diarrheal agent, but it usually induces constipation. This study is to compare the efficacy, safety, and tolerability of racecadotril versus loperamide in the outpatient treatment of acute diarrhea in adults.

Rev Gastroenterol Disord. 2008 Winter;8(1):15-20.

Hanauer SB.

Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, Illinois, USA.

Loperamide is an effective therapy for a variety of diarrheal syndromes, including acute, nonspecific (infectious) diarrhea; traveler's diarrhea; and chemotherapy-related and protease inhibitor associated diarrhea. Loperamide is effective for the "gut-directed" symptom of diarrhea in patients with painless diarrhea or diarrhea-predominant irritable bowel syndrome.

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